This article comprehensively examines sucralose, an artificial sweetener used worldwide, focusing on its gastrointestinal effects, especially its potential to cause diarrhea. It explains sucralose's interference with gut microbiota and intestinal lining, links to inflammatory bowel diseases, metabolic implications, and safety concerns including immune and organ effects. Practical advice on managing symptoms and FAQs round out the discussion for an informed understanding of sucralose consumption and health.