This article evaluates whether artificial sweeteners are harmful to liver health, highlighting scientific research on their potential to cause oxidative stress, disrupt detoxification, and increase risks of fatty liver disease and cancer. By emphasizing moderation and safer natural sweeteners, it supports the industry's move toward healthier solutions in food, beverage, and healthcare products. For manufacturers specializing in natural sweeteners, functional polyols, and dietary fibers, balancing sweetness with health safety is key to developing innovative and health-forward products.