This article provides an in-depth analysis of sucralose safety, supported by scientific evidence and regulatory positions. It outlines the acceptable intake levels, metabolic profile, potential health impacts, and practical consumption advice. While sucralose is generally safe within recommended limits, emerging research highlights areas for continued study, especially regarding metabolic and gut microbiome effects. Proper moderation ensures sucralose remains a useful tool in reducing sugar intake without compromising health.

Sucralose, a popular artificial sweetener, has raised concerns regarding its potential cancer risks. Emerging studies highlight sucralose's ability to cause DNA damage, disrupt gut health, trigger inflammation, and reduce cancer immunotherapy efficacy. While regulatory agencies uphold its safety at moderate intakes, recent evidence suggests caution and the exploration of natural alternatives and supportive strategies like arginine supplementation.