Sucralose, a popular artificial sweetener, has raised concerns regarding its potential cancer risks. Emerging studies highlight sucralose's ability to cause DNA damage, disrupt gut health, trigger inflammation, and reduce cancer immunotherapy efficacy. While regulatory agencies uphold its safety at moderate intakes, recent evidence suggests caution and the exploration of natural alternatives and supportive strategies like arginine supplementation.

This article reviews current scientific evidence surrounding sucralose, a popular artificial sweetener, and its possible carcinogenic effects. Although regulatory agencies uphold sucralose's safety within recommended limits, recent studies reveal that certain sucralose derivatives may cause DNA damage and gut inflammation linked to cancer. The article offers a comprehensive analysis of research findings, regulatory perspectives, mechanisms involved, and answers frequently asked questions to help readers understand the ongoing debate about sucralose and cancer risk.