This article compares sucralose and stevia, two popular zero-calorie sweeteners used in food, beverage, and healthcare industries. It covers their origins, sweetness levels, taste profiles, stability, safety, and applications. While sucralose is a synthetic sweetener with sugar-like taste and heat stability, stevia is a natural plant extract with a distinct licorice flavor. Both are safe and effective sugar alternatives, with unique advantages for product development and consumer preferences.