This article provides an in-depth comparison of Stevia and Aspartame, two popular sugar substitutes. Stevia, a natural extract from a plant, offers intense sweetness and potential metabolic benefits but has a distinctive aftertaste. Aspartame, a synthetic sweetener, closely mimics sugar's taste but requires caution for sensitive individuals and those with PKU. Both are considered safe alternatives to sugar when consumed responsibly and can aid in reducing calorie and sugar intake for improved health outcomes.