This article clarifies that Xylitol is not an ingredient in Splenda products, which instead use sucralose as their primary sweetener. It explores their different chemical properties, applications, health effects, and industry uses, helping consumers and manufacturers understand how these popular sugar substitutes fit into health-oriented food, beverage, and healthcare products. Our expertise in natural sweeteners and polyols supports OEM/ODM manufacturers with customized mixed sweetener solutions that balance sweetness, calories, and texture.