This article provides an in-depth analysis of whether sucralose leads to weight gain by investigating its effects on appetite regulation, metabolism, gut microbiota, and inflammation. While sucralose is calorie-free and widely used in health-focused foods and medical products, emerging evidence indicates it may increase hunger and alter metabolic processes, potentially contributing to weight gain in certain populations. The article offers practical guidance for both consumers and manufacturers on the mindful use of sucralose within balanced dietary and product formulations to support metabolic health and weight management.

Artificial sweeteners, though calorie-free, may paradoxically cause weight gain by altering gut microbiota, disrupting appetite signals, and promoting fat storage. Careful consumption and exploring alternatives are recommended for healthier weight management. "Sweeteners" impact metabolism beyond sweetness alone.