This article provides a comprehensive overview of how sucralose, a popular artificial sweetener, is processed and eliminated in the human body. It explains that the majority of sucralose passes through the digestive system unchanged and is excreted in feces, while a small portion absorbed is eliminated via urine within about 18 hours. The article discusses sucralose's minimal metabolism, potential effects on gut microbiota, implications for special populations, and overall safety profile. Practical advice on consumption and emerging research findings complete this detailed guide for consumers and professionals alike.