Splenda and sucralose are often confused, but Splenda is a brand containing sucralose plus fillers, while pure sucralose is used in industrial applications. Both are safe, versatile sweeteners widely used in food, beverage, and healthcare industries.

This article clarifies that sucralose is the chemical sweetener, while Splenda is a branded product containing sucralose plus fillers. Both are used widely as sugar substitutes in foods and beverages. Sucralose is 600 times sweeter than sugar and calorie-free, stable in cooking and baking. Current evidence supports their safety in moderation, with ongoing research on potential effects on metabolism, immunity, and gut health.