This article comprehensively evaluates the healthiest artificial sweeteners as of 2025, highlighting natural sweeteners like stevia and monk fruit as preferred options due to safety and health benefits. It reviews synthetic sweeteners, emerging research on cognitive and cardiovascular risks, and developmental concerns. Practical advice emphasizes moderation, awareness of individual health contexts, and staying updated on scientific findings regarding sweeteners' long-term effects. This knowledge supports healthier food and beverage innovation focused on balanced sweetness solutions.