Acesulfame potassium and aspartame are key artificial sweeteners used worldwide to replace sugar in low-calorie products. They differ chemically: aspartame is a dipeptide sweetener that is heat sensitive and contains phenylalanine; acesulfame potassium is a heat-stable potassium salt with no calories. Blended together, they provide a balanced sweetness with minimized aftertaste. Both are FDA-approved and generally safe for consumers, except aspartame should be avoided by those with PKU. Understanding their differences helps manufacturers optimize product development, ensuring delicious, healthier alternatives for the market.